Klotho Protein and Diabetes Mellitus

Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes death in western societies. In development disease, underlying pathophysiological mechanisms are complex multifactorial. The frequency DM increases with age, severity events such oxidative stress inflammation patients diagnosed DM. Klotho (KL) protein, defined a new anti-aging protein result studies on aging it has important functions glucose homeostasis insulin secretion. this review study, relationship between KL explained compiling information articles published PubMed indexed journals 2002-2020. conclusion, decrease levels plays role type 2 nephropathy vascular diseases caused